Network pharmacology study on the mechanism of the tong xie yao fang in treating irritable bowel syndrome

• 作者: Hai-Long Shi Meng-Lin Yue Shan-Shan Zhang Xin-Rong Guo
• 来源期刊: 精准医学研究
• 学科: 医学
• 关键词: Network PHARMACOLOGY Tongxieyao FORMULA IRRITABLE BOWEL syndrome Target prediction MECHANISM of action
• 年，卷（期）: 2019,（1）
• 页码范围: 17-25
• 页数: 9页
• 分类号: R

摘要

Objective:The purpose of this study was to explore the effective compounds and molecular mechanism of Tong Xie Yao Fang(TXYF)in the treatment of Irritable Bowel Syndrome(IBS)based on network pharmacology.Method:The effective components in TXYF were screened using the TCMSP database,and the targets were predicted and analyzed with the PharmMapper server.The potential targets were imported into the MAS 3.0 database for target annotation and analysis.Finally,the KEGG database was used for pathway analysis.Result:Forty-three compounds were identified in the TXYF,corresponding to 247 targets.Among these,a total of 33 targets were found to be closely related to IBS.Pathway enrichment analysis identified 22 significant pathways to be associated with TXYF and its treatment.The results showed that components such as polyphenols,flavonoids,and terpenoids can enhance the immune function and alter hypoxia-induced stress by regulating cell proliferation,oxidative reactions,endocrine metabolism,and inflammatory reactions.Conclusion:The mechanism of TXYF in treating IBS is closely related to metabolic reactions,cell proliferation,inflammatory reactions,immune regulation,and endocrine hormone metabolism.