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摘要:
Urothelial carcinoma of bladder is the second most prevalent genitourinary disease.It is a highly heterogeneous disease as it represents a spectrum of neoplasms,including non-muscle invasive bladder cancer(NMIBC),muscle invasive bladder cancer(MIBC)and metastatic lesions.Genome-wide approaches and candidate gene analysis suggest that malignant transformation of the bladder is multifactorial and a multitude of genes are involved in the development of MIBC or NMIBC phenotypes.Wnt signaling is being examined to control and maintain balance between stemness and differentiation in adult stem cell niches.Owing to its participation in urothelial development and maintenance of adult urothelial tissue homeostasis,the components of Wnt signaling are reported as an important diagnostic and prognostic markers as well as novel therapeutic targets.Mutations/epigenetic alterations in the key molecules of Wnt/β-catenin canonical pathway have been linked with tumorigenesis,development of drug resistance and enhanced survival.Present review extends our understanding on the functions of key regulatory molecules of canonical Wnt/β-catenin pathway in urothelial tumorigenesis by inducing cancer stem cell phenotype(UCSCs).UCSCs may be responsible for tumor heterogeneity,high recurrence rates and complex biological behavior of bladder cancer.Therefore,understanding the role of UCSCs and the regulatory mechanisms that are responsible for high relapse rates and metastasis could help to develop pathway inhibitors and augment current therapies.Potential implications in the treatment of urothelial carcinoma of bladder by targeting this pathway primarily in UCSCs as well as in bulk tumor population that are responsible for high relapse rates and metastasis may facilitate potential therapeutic avenues and better prognosis.
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篇名 WNT/β-catenin signaling in urothelial carcinoma of bladder
来源期刊 世界肾病学杂志:英文版 学科 医学
关键词 CHEMORESISTANCE THERAPEUTIC APPROACHES UROTHELIAL carcinoma of BLADDER UROTHELIAL cancer stem cells WNT/Β-CATENIN
年,卷(期) 2019,(5) 所属期刊栏目
研究方向 页码范围 83-94
页数 12页 分类号 R737.11
字数 语种
DOI
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研究主题发展历程
节点文献
CHEMORESISTANCE
THERAPEUTIC
APPROACHES
UROTHELIAL
carcinoma
of
BLADDER
UROTHELIAL
cancer
stem
cells
WNT/Β-CATENIN
研究起点
研究来源
研究分支
研究去脉
引文网络交叉学科
相关学者/机构
期刊影响力
世界肾病学杂志:英文版
不定期
2220-6124
北京市朝阳区东四环中路62号楼远洋国际中
出版文献量(篇)
35
总下载数(次)
0
总被引数(次)
0
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