Role of endoscopy in the management of primary sclerosing cholangitis

• 作者: James H Tabibian Neil Bharat Marya
• 来源期刊: 世界胃肠内镜杂志:英文版(电子版)
• 学科: 医学
• 关键词: BILE duct diseases CHOLANGIOCARCINOMA Inflammatory bowel disease Endoscopic RETROGRADE CHOLANGIOPANCREATOGRAPHY Biopsy Primary SCLEROSING CHOLANGITIS
• 年，卷（期）: 2019,（2）
• 页码范围: 84-94
• 页数: 11页
• 分类号: R

摘要

Primary sclerosing cholangitis(PSC)is a rare but prominent fibroinflammatory cholangiopathy which can affect individuals of essentially any age.It carries a median survival of 15-20 years,regardless of age at diagnosis,and is a foremost risk factor for cholangiocarcinoma.Given the chronic and progressive nature of PSC,its inherent risk for biliary tract and other complications,and the paucity of effective pharmacotherapies,endoscopy plays a major role in the care of many patients with this disorder.In this review,we discuss the endoscopic management of PSC,including established and evolving approaches to the diagnosis and treatment of its benign as well as malignant sequelae.Owing to the rarity of PSC and dearth of high-quality evidence,we propose pragmatic approaches based on both currently available data and expert opinion.