Background: Overweight and obesity are escalating global problem, causing multiple life threatening non-communicable diseases including cardiovascular disease, dyslipidemia, hypertension, type 2 diabetes, osteoarthritis and some forms of cancer [1] [2]. Although the burden is particularly heavy in developing countries including Kenya, yet extensive data is still lacking in these countries. Therefore, the aim of this study was to determine the prevalence and risk factors for obesity and overweight among the Catholic University of Eastern Africa (CUEA) staff, Langata Campus, Nairobi, Kenya. Methods and Materials: A cross sectional, descriptive study was carried out among 301 CUEA staff. WHO stepwise-structured questionnaire was used to collect the data regarding respondents’ socio-demographic, lifestyle characteristics and anthropometric. Data were analyzed using SPSS software version 22.0. Descriptive Data were descriptively analyzed into proportions and frequency tables, while to determine relationships between various variables;One-Way ANOVA was employed. The ethical approval to conduct the study was obtained from KNH-University of Nairobi Ethical Review Committee. The institutional permission was granted by the administration of CUEA. The consent was obtained from the respondents before data collection was commenced. Results: The prevalence of overweight and obesity among the respondents was 47.5% and 36.3% respectively. Based on waist circumference (WC), the prevalence of overweight and obesity among men was 42.6% and 37.2% respectively. While among the women the prevalence of overweight and obesity was 56.8% and 19.5% respectively. The mean BMI (p = 0.006) and the mean WC (p = 0.004) were significantly higher among respondents aged ≤40 years old. Additionally, the mean WC was significantly higher among male respondents compared to the female counterparts (p = 0.003). Daily consumption of vegetables (p = 0.022) and fruits (p = 0.017) was significantly associated with lower WC. While, higher WC (p = 0.015)