Metabolites from marine invertebrates and their symbiotic microorganisms: molecular diversity discovery, mining, and application

• 作者: Chang-Lun Shao Chang-Yun Wang Lu Liu Yao-Yao Zheng
• 来源期刊: 海洋生命科学与技术(英文)
• 学科: 经济
• 关键词: MARINE invertebrates SYMBIOTIC MICROORGANISMS MARINE natural products Molecular diversity BIOACTIVITIES MARINE DRUGS
• 年，卷（期）: 2019,（1）
• 页码范围: 60-94
• 页数: 35页
• 分类号: F42

摘要

Metabolites from marine organisms have proven to be a rich source for the discovery of multiple potent bioactive moleculeswith diverse structures. In recent years, we initiated a program to investigate the diversity of the secondary metabolites frommarine invertebrates and their symbiotic microorganisms collected from the South China Sea. In this review, representativecases are summarized focusing on molecular diversity, mining, and application of natural products from these marineorganisms. To provide a comprehensive introduction to the field of marine natural products, we highlight typical moleculesincluding their structures, chemical synthesis, bioactivities and mechanisms, structure-activity relationships as well as biogenesis. The mining of marine-derived microorganisms to produce novel secondary metabolites is also discussed through theOSMAC strategy and via partial chemical epigenetic modification. A broad prospectus has revealed a plethora of bioactivenatural products with novel structures from marine organisms, especially from soft corals, gorgonians, sponges, and theirsymbiotic fungi and bacteria.