Objective:The meta-analysis is to objectively evaluate the efficacy of swaddling in neonates.Methods:Randomized controlled trials(RCTs)and Randomized cross-over design(RCD)about the effects of swaddling in neonates from multiple electronic databases(PubMed,Web of Science,the Cochrane Library,EMBASE,CINAHL,CNKI,Wanfang and VIP)until January 2019.Two investigators independently screened eligible studies,extracted data,and assessed the methodological quality by using the quality evaluation criteria for RCTs recommended by Cochrane Handbook.Then data were analyzed by Rev Man 5.3.Results:A total of 6 papers(4 randomized controlled trials and 2 Randomized cross-over design)with 318 participants were included.The meta-analysis indicated that there was a significant difference on Body Temperature,Heart Rate,crying time,incidence of open eyes and incidence of closed eyes(P<0.05);There was no significant difference in Spo2 level between the two groups(p>0.05).Conclusion:Swaddling bath has little influence on the Body Temperature,Heart Rate,and behavioral response of newborn.And it has no significant effect on maintaining Spo2 level.However it can reduce the stress behavior of the newborn.Due to the limitations of the quality of studies included,multi-centered randomized controlled trial large sample size are needed in the future to evaluate the effects of prone position ventilation on neonatal respiratory distress syndrome.