Despite the rapid development of diagnostic and therapeutic modalities and techniques to manage LGIB patients from interventional radiology’s standpoint,a successful localization of the bleeding site that leads to an effective embolotherapy remains a significant technical challenge.The interventional radiologist’s decisions when managing patients with LGIB may significantly impact the clinical outcomes;therefore,management should be made based on careful and thorough considerations of factors such as etiology,locations,patient’s comorbidities,and potential post-procedure complications,among others.The purpose of this paper is to review the management of LGIB by interventional radiology,focusing on a few challenging and common clinical situations that require special consideration by interventional radiologists.