Due to persistent or low-intensity stimulation,tissue cells are in a state of injury for a long time,and the inflammatory state continues,eventually leading to nonresolving inflammation.In this nonresolving inflammation,various inflammatory mediators and inflammatory cells act on tissue cells,and tumors are easily induced.Further,the unique microenvironment of the tumor further aggravates the development of uncontrolled inflammation.Eventually a vicious circle is formed.In this paper,we explored the mechanism of inflammatory mediators,inflammatory cells and tumors in nonresolving inflammation from the relationship between nonresolving inflammation and tumors,and provided some new ideas for the prevention and treatment of tumors.