Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold

• 来源期刊: 药学学报（英文版）
• 关键词: Hybrid inorganic-organic Drug delivery Camptothecin Gold nanoparticles Computed tomography (CT) contrast agent Cancer therapy and diagnosis
• 年，卷（期）: 2019,（1）
• 页码范围: 128-134
• 页数: 7页
• 语种: 英文

摘要

We demonstrate a novel inorganic-organic crystalline nanoconstruct,where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals,suggesting its potential use as simultaneous agents for cancer therapy and bioimaging.The incorporation of gold,a potential computed tomography (CT) contrast agent,in the nanocrystals of camptothecin was detected by transmission electron microscope (TEM) and further quantified by energy dispersive X-ray spectrometry (EDS) and inductively coupled plasma-optical emission spectrometers (ICP-OES).Due to gold's high attenuation coefficient,only a relatively small amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging.The imbedded gold atoms and clusters are expected to share the same biological fate as the camptothecin nanocrystals,reaching and accumulating in tumor site due to the enhanced permeation and retention (EPR) effect.