The involvement of anti-neurofascin 155 antibodies in central and peripheral demyelinating diseases

• 作者: Marcus Vinicius Magno Goncalves Yara Dadalti Fragoso
• 来源期刊: 神经免疫与神经炎症（英文版）
• 年，卷（期）: 2019,（4）
• 所属期刊栏目: Letter to Editor
• 页码范围: 1-3
• 页数: 3页
• 语种: 英文
• DOI: 10.20517/2347-8659.2019.08

摘要

The immunological aspects of autoantibodies directed against paranodal and nodal proteins form a prominent field of research. Contactin-1 and contactin-1 associated protein, gliomedin and neurofascin (NF) are Ranvier node-related proteins[1,2]. Antibodies against these proteins have been identified in chronic demyelinating conditions, such as multiple sclerosis (MS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP); and in acute demyelinating diseases such as Guillain-Barre syndrome[3,4]. Myelin and the paranodal axoglial junctions flanking the nodes of Ranvier are not merely passive transmitters of electric signals: instead, they have essential roles in maintaining the structural integrity of myelin-axolemmal interactions, bidirectional signaling and regulation of ion channels[5].