Amorphous Calcium Salt Composition Bioavailability Evaluation in Chickens

• 作者: D. Babarykin G. Krumina G. Smirnova M. Mutalova N. Basova R. Simanis S. Vasiljeva V. Agejchenko
• 来源期刊: 生物科学与医学(英文)
• 学科: 医学
• 关键词: CALCIUM ABSORPTION AMORPHOUS CALCIUM Experimental RICKETS CHICKEN
• 年，卷（期）: 2019,（2）
• 页码范围: 15-25
• 页数: 11页
• 分类号: R73

摘要

Despite the market saturation with a wide range of calcium preparations in dietary supplements as well as in pharmaceuticals, calcium product safety and efficacy remain an item for further optimization. Bones and teeth mainly consist of calcium phosphate, but tablets and capsules are predominantly produced from calcium carbonate. On the other hand, in human food Ca2+ is bound with a lot of anions—carbonates, sulphates, chlorides, phosphates, citrates, oxalates etc. It seems that traditional calcium formulations due its low bioavailability cannot provide all spectra of biological calcium-dependant effects and dietary calcium might be safer and more effective than traditional calcium supplements and medicines. To increase calcium salt efficacy a new formulation of calcium salts has been developed. It is a mixture (water suspension) of amorphous calcium carbonate, citrate, hydrocarbonate, as well as magnesium hydrocarbonate and hydrocitrate as stabilizers. The capacity of a cockerel’s duodenal mucosa to absorb Ca2+ after peroral ingestion of the mentioned composition in vivo was as much as 126% higher in comparison with CaCO3 suspension intake. Vitamin D3 enhanced the amorphous antirachitic activity of calcium salts. The aim of the study was to compare original amorphous calcium salt composition bioavailability with Ca salts most often in food and medicines, as well as to evaluate the antirachitic activity of the mentioned composition in combination with vitamin D3 in chickens.