Uremic clearance granule combined with Alprostadil in the treatment of chronic renal failure: A systematic review and meta-analysis

• 作者: Dong-Dong Li Jia-Bao Zhou Jian-Dong Gao Jing Gan Ya-Fang Guo Zi-Zheng Zhou
• 来源期刊: TMR理论与假说
• 学科: 医学
• 关键词: UREMIC CLEARANCE GRANULE Chronic RENAL Failure ALPROSTADIL META-ANALYSIS
• 年，卷（期）: 2019,（3）
• 页码范围: 195-203
• 页数: 9页
• 分类号: R

摘要

Objective: To evaluate whether the combination of Uremic clearance granule with Alprostadil is superior to Alprostadil alone for CRF. Methods: Relevant RCTs were searched through March 2019. Data were analyzed by Stata 15.0. Results: Nine articles involving 726 patients were enrolled in this study. Meta-analysis showed that the total effective rate [OR = 3.68 (2.44, 5.55), P < 0.001], Scr [SMD =-2.34 (-3.49,-1.19), P < 0.001], BUN [SMD =-1.80 (-2.73,-0.87), P < 0.001], Ccr [SMD = 0.71 (0.44, 0.97), P < 0.001] were better in the experimental group. But there were no significant difference in UA, CysC, 24h-Upro and incidence of adverse reactions (all P > 0.05) between two groups. No serious adverse reactions were found. Conclusions: The effect of the integrated medicine on CRF was better than Alprostadil alone. Uremic clearance granule is safe and has no obvious adverse reactions.