A meta-analysis of Duhuo Jisheng decoction combined with non-operative therapy on lumbar disc herniation

• 作者: Chen-Yang Zhang Ling Li Shao-Feng Yang Xiao-Nan Wu Zhao-Yong Li
• 来源期刊: TMR临床研究
• 学科: 医学
• 关键词: Duhuo Jisheng decoction(DHJSD) LUMBAR DISC herniation(LDH) META-ANALYSIS Randomizedcontrolled trials(RCTs)
• 年，卷（期）: tmrlcyj_2019,（3）
• 页码范围: 115-124
• 页数: 10页
• 分类号: R

摘要

Objective:To systematically evaluate the cllinical efficacy of Duhuo Jisheng decoction(DHJSD)combined with non-surgical therapy on lumbar disc herniation(LDH).Methods:China Science and Technology Journal Database(VIP),Chinese National Knowledge Infrastructure(CNKI),WanFang Data,PubMed were searched and eligible randomized controlled clinical trials(RCTs)were included.Two reviewers evaluated the quality of the included RCTs and extracted data independently.Then,data analysis was performed with RevMetn 4.2 software.Results:A total of 18 RCTs were enrolled,including 1682 patients.Meta-analysis results showed that the overall response rate of DHJSD combined with non-operative therapy group(treatment group)in the treatment of LDH was better than that of the non-operative therapy group(control group)[OR=4.29,95%CI(3.19,5.76),P<0.001].JOA score of the treatment group was significantly higher than that of control group[OR=3.96,95%CI(3.4,4.52),P<0.001].VAS score was dramatically lower in the treatment group than the control group[OR=-1.58,95%CI(-1.97,-1.18),P<0.001].Conclusion:The clinical efficacy of DHJSD combined with non-surgical therapy is better than that of non-surgical therapy alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.