Shanghan Zabing Lun,an acient book of Chinese medicine that published in Han dynasty(219 C.E.),is the first monograph in China that has the principles of prescription and treatment.Modern physicians flexibly applied many classical prescriptions recorded on this acientd book,such as Banxia Xiexin decoction,Da Chengqi decoction,Yiyi Fuzi Bijiang decoction and Wumei pill for the treatment of colorectal cancer and its complications,and made some progress in clinical and experimental research.Studies have shown that classical prescriptions alone or in combination with other therapies can improve immunity,prevent cancer from recurrence and metastasis,reduce the side effects of anticancer drugs,improve quality of life,and prolong the survival of cancer patients.However,the current clinical and mechanistic studies on the treatment of classical prescriptions still need to explore in depth.This study aims to summarize the clinical and research progress in the treatment of colorectal cancer with classical prescriptions in recent years.