Dissecting the underlying pharmaceutical mechanism of traditional Chinese medicine Wenxin Keli acting on atrial fibrillation through network pharmacology

• 作者: Chen Chen Wei Mao Xian-Jun Wu Xin-Bin Zhou
• 来源期刊: 药物联合治疗
• 学科: 医学
• 关键词: Network pharmacology traditional Chinese medicine WENXIN Keli ATRIAL FIBRILLATION PHARMACOLOGICAL MECHANISM
• 年，卷（期）: 2019,（3）
• 页码范围: 117-133
• 页数: 17页
• 分类号: R

摘要

As a well-known Chinese medicine prescription, Wenxin Keli (WXKL) has been widely used in the treatment of many arrhythmias including atrial fibrillation and has achieved significant clinical effects, but the specific mechanism of its treatment of atrial fibrillation remains unclear. This study used a network pharmacology approach to reveal the potential molecular mechanisms of WXKL in the treatment of atrial fibrillation. It involves oral bioavailability screening of ingredients, drug-likeness evaluation, compound target fishing, H-C-T network and C-T-P network construction and analysis. Through the network pharmacology-based research strategy, the complex system of WXKL was analyzed. It was found that 14 representative compounds of WXKL, 30 protein targets and 12 related signaling pathways help us systematically understand the underlying mechanism of WXKL’s anti-atrial fibrillation effects.