The detailed anti-tumor mechanisms of daphnanetype diterpenoids from Genkwa flos

• 作者: Fengying Han Guodong Yao Jingjie Chen Shaojiang Song Xinyue Shang Yan Zhang
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: daphnane-type DITERPENOIDS Genkwa flos ANTI-TUMOR
• 年，卷（期）: yzctyy_2019,（1）
• 页码范围: 43-51
• 页数: 9页
• 分类号: R

摘要

Genkwa flos is a well-known traditional Chinese medicine, which exhibits abundant biological activities such as antiinflammatory, analgesic, immunoregulatory activities and anti-rheumatic arthritis activity. Recent pharmacological studies showed that Genkwa flos might also have the antitumor effect. Daphnane-type diterpenoids (DDs) are one of the main anti-tumor constitutions in Genkwa flos. However, the underlying anticancer molecular mechanisms of this type of compounds are still unclear. This review aims to give a systematic summary of DDs from Genkwa flos to better understand the anti-tumor activitiy by focusing on cell arrest, apoptosis, topoisomerase inhibition, melanin inhibition and the reverse of multi-drug-resistance (MDR). In addition, we are also going to make an overview of the mechanisms identified up to now. The significant findings may provide that DDs in Genkwa flos is a promising targeted-cancer agent.