Research Progress on Post-Traumatic Stress Disorder and Its Animal Model

• 作者: Jianhong Pan Juncheng Guo Min Guo Ping Huang Xiang Li Xiangling Jiang Yijun Yang Zhuo Liu
• 来源期刊: 行为与脑科学期刊(英文)
• 学科: 医学
• 关键词: POST-TRAUMATIC STRESS DISORDER ANIMAL Model REVIEW
• 年，卷（期）: 2019,（4）
• 页码范围: 174-183
• 页数: 10页
• 分类号: R73

摘要

Posttraumatic stress disorder (PTSD) is to a persistently severe mental disorder which is caused by individual exposure to some unusual threatening or catastrophic stressful events. Its essential clinical manifestations refer to repeated playback of traumatic experience, durative avoidance of related clues, mental numbness or affection paralysis, and persistent increase of vigilance level. At present, the pathogenesis of PTSD has not been fully elucidated, and the clinical therapeutic effect has not been ideal. Generally, the classical animal model of PTSD is mouse;the domestic and international researches in the animal model of PTSD in recent years remain active, which are summarized as follows.