Lower level of copper and zinc in serum confer risk to vitiligo: a systematic review and meta-analysis

• 作者: Hao-Tian Li Jian-Xia Wen Shi-Zhang Wei Tao-Yang Tian-Bao Xiao Wan-Ling Liang Yi-Bo Cao
• 来源期刊: TMR临床研究
• 学科: 医学
• 关键词: VITILIGO COPPER ZINC Systematic review META analysis
• 年，卷（期）: 2019,（4）
• 页码范围: 137-147
• 页数: 11页
• 分类号: R75

摘要

Etiology and pathogenesis of vitiligo has not been interpreted perfectly.Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory.We investigated the association between blood serum copper and zinc with vitiligo via performing a meta-analysis.Results indicates there was a significant lower level of copper and zinc in patients with vitiligo compared with healthy population((Z=3.55,P=0.000;SMDCu=?0.84,95%CI,?1.30 to?0.38)and(Z=5.40,P=0.000;SMDZn=?1.01,95%CI,?1.38 to?0.64),respectively).Meanwhile,no statistical evidence for publication bias in the end outcome.Conclusion from our finding offers a meaningful insight into lower level of copper and zinc in serum confer risk to vitiligo.