Supramolecular nanoscale drug-delivery system with ordered structure

• 来源期刊: 国家科学评论（英文版）
• 关键词: supramolecular chemistry drug-delivery system host-guest recognition self-delivery system precision medicine
• 年，卷（期）: 2019,（6）
• 页码范围: 1128-1137
• 页数: 10页
• 语种: 英文
• DOI: 10.1093/nsr/nwz018

摘要

Supramolecular chemistry provides a means to integrate multi-type molecules leading to a dynamic organization.The study of functional nanoscale drug-delivery systems based on supramolecular interactions is a recent trend.Much work has focused on the design of supramolecular building blocks and the engineering of supramolecular integration,with the goal of optimized delivery behavior and enhanced therapeutic effect.This review introduces recent advances in supramolecular designs ofnanoscale drug delivery.Supramolecular affinity can act as a main driving force either in the self-assembly of carriers or in the loading of drugs.It is also possible to employ strong recognitions to achieve self-delivery of drugs.Due to dynamic controllable drug-release properties,the supramolecular nanoscale drug-delivery system provides a promising platform for precision medicine.