Single nucleotide polymorphism rs11191454 in arsenite methyltransferase is associated with flow in Chinese students: a genetic study on flow experience

• 作者: An Lin Bai Bo Bi Yan Chen Zhixuan Du Li Guo Zhenming He Guang He Lin Ji Lei Li Xingwang Liu Chuanxin Ma Gaini Ren Decheng Shi Lei Sun Qianqian Xu Fei Xu Yifeng Yang Fengping Yu Tao Yuan Fan Yuan Ruixue Zhang Naixin Zhu Liping
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: arsenic metabolism AS3MT association study flow single nucleotide polymorphism
• 年，卷（期）: 2019,（3）
• 所属期刊栏目: Research Article
• 页码范围: 140-144
• 页数: 5页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000042

摘要

Flow has been widely studied in the field of positive psychology. However, little is known regarding its biological mechanism. This study aimed to ascertain flow-related gene loci. We investigated the association between flow and five single nucleotide polymorphisms associated with common mental disorders among a sample of 870 healthy 1 st year students of Jining Medical University, Shandong Province, China. This study was approved by the Ethics Committee of Jining Medical University (approval number: JNMC-2016-KY-001) on June 1, 2016. rs11191454 demonstrated significant statistical association with flow after adjusting for age and gender ( P= 0.004). The allele carriers achieved higher scores in all 4 dimensions of flow: merging of action and awareness, challenge-skill balance, sense of control, and clear goals. This biological research article indicates that rs11191454 in the arsenite methyltransferase ( AS3MT) gene might be associated with flow in a Chinese Han population, and that might result from altered arsenic metabolism.