Network pharmacology-based prediction and verification of the molecular targets and pathways for Piper longum Linn,against liver cancer

• 作者: Jie Wang Liwei Lu Shaojiang Song Xiaoxiao Huang
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: liver cancer PIPER longum Linn. NETWORK PHARMACOLOGY pathway NETWORK
• 年，卷（期）: 2019,（4）
• 页码范围: 183-192
• 页数: 10页
• 分类号: R73

摘要

Liver cancer is a common malignant tumor,which is one of the most common causes of cancer related deaths worldwide,specially,in China.Piper longum Linn,is a traditional Chinese medicine that is used to treat and prevent diseases in clinical practice,however,the active ingredients and potential targets of its action against liver cancer remain unclear.In this study,network pharmacology approach was used to identify active ingredients and the major targets of Piper longum against liver cancer.In addition,the key pathways were also predicted on the network pharmacology level,which might be beneficial to the chemical basis and pharmacological studies of this plant.