Research progress of the relationship between microvesicles derived from stem cells and nervous system diseases

• 作者: Fuhao Qiao Jiaping Yan
• 来源期刊: TMR生命研究
• 学科: 生物学
• 关键词: STEM cells MICROVESICLES Nervous system DISEASES BIOLOGICAL therapy
• 年，卷（期）: 2019,（4）
• 页码范围: 145-151
• 页数: 7页
• 分类号: Q

摘要

Microvesicles, also called microparticles, are membranous vesicles released from the cell membrane surface or by exocytose. Almost any type of cells can secrete vesicles, especially stem cells. Recent years, stem cells are becoming a research hotspot of cytotherapy for their capacity of self-renewing, expansion and proliferation in vitro and the microvesicles derived from the conditioned medium of stem cells have been widely used to regenerative medicine because they are safer, easily obtained, measurable and cause no obvious immune rejection. Stem cells derived microvesicles have been confirmed to be closely related to the progress and treatment of atherosclerosis, diabetes, inflammation and tumor. This review focuses on the new progress of stem cells derived microvesicles treating various nervous system diseases and its application in biological therapy and the behind molecule mechanisms.