The Diagnostic Role of Brain MRI in Detection of Multiple Sclerosis Related Cognitive Impairment

• 作者: Aymen Abd Elnaby Maha Bilal Mohamed Saad Wael Gabr
• 来源期刊: 行为与脑科学期刊(英文)
• 学科: 医学
• 关键词: Multiple SCLEROSIS COGNITIVE IMPAIRMENT MRI CORTICAL Brain LESION MS RELATED CI
• 年，卷（期）: 2019,（8）
• 页码范围: 313-324
• 页数: 12页
• 分类号: R73

摘要

Background: Cognitive impairment (CI) is a common manifestation of multiple sclerosis (MS), which can severely affect patients’ and their families’ life. Early suspicion and detection of CI can improve general medical management of MS patients. Objectives: To correlate MS related CI to cortical brain lesions using brain magnetic resonance imaging (MRI). Materials and Methods: Cognitive impairment was detected using mini mental state examination (MMSE);Neurological examination and brain MRI were performed for all patients. Correlation was calculated between disease cortical burden detected by MRI and CI. Results: Fifty-three patients with proven MS were scanned by brain MRI;69.8% of them had cognitive impairment diagnosed with MMSE. The presence and severity of cognitive impairment was correlated to cortical brain lesion. Cognitive impairment was not correlated with non-cortical brain lesions or neurological physical disability measured by Expanded Disability Status Scale (EDSS). Conclusions: Presence of brain frontal cortical lesions detected by MRI in MS patients can predict subsequent development of MS-related CI.