An inflammatory subtype of pancreatic ductal adenocarcinoma is associated with poor prognosis and increased perioperative mortality

• 作者: Bahra Marcus Benzing Christian Klein Fritz Pelzer Uwe Pratschke Johann Sinn Marianne
• 来源期刊: 胰腺病学杂志（英文）
• 关键词: Cholangitis CRP Inflammatory carcinoma PDAC
• 年，卷（期）: 2019,（3）
• 所属期刊栏目: Original Article
• 页码范围: 107-112
• 页数: 6页
• 语种: 中文
• DOI: 10.1097/JP9.0000000000000022

摘要

Pancreatic ductal adenocarcinoma (PDAC) is a malignancy characterized by an aggressive tumor behavior. The present analysis seeks to identify and analyze a cohort that meets criteria for "inflammatory" PDAC (IPDAC). All patients who underwent a curative resection for PDAC at our institution between 1989 and 2015 were included in the retrospective analysis. Patients with histological proven adenocarcinoma and elevated C-reactive protein (CRP) (≥6 mg/L) serum concentrations, but no other suspicion of infection were included. We provide a matched control group with normal CRP serum levels from the same patient cohort. Thirty-six (6.8%) of 532 patients meet our criteria for an IPDAC group type. In-hospital (30 days) mortality was 13.9% in the IPDAC group vs 0% in the control group ( P=.020). Median follow-up was 183.8 months (standard deviation [SD]= 53.3, range 14.3-285.4). Median overall survival was 8.5 months (SD= 16.8, range 0.3-89.6) in the IPDAC group and 24.8 months (SD= 19.4, range 0.7-80.4) in the control group ( P=.002). Patients indicating an IPDAC in our cohort had a significantly and clinical meaningful decreased overall survival and a higher perioperative morbidity and mortality.