Network pharmacology-based virtual screening of natural products from Peperomia dindygulensis for the application to treat liver cancer

• 作者: Han Zhang Peng Zhao Xiaoxiao Huang Zhikang Duan Zhiyang Yan
• 来源期刊: 亚洲传统医药
• 学科: 医学
• 关键词: PEPEROMIA dindygulensis network PHARMACOLOGY potential TARGET biological PATHWAY
• 年，卷（期）: 2019,（6）
• 页码范围: 253-259
• 页数: 7页
• 分类号: R73

摘要

Traditional Chinese medicine plays an increasingly important role in cancer treatment for the property of the complex components and multi-targets.Peperomia dindygulensis,belonging to Piperaceae family,was proved to be effective to the treatment of cancer,but the action mechanism is incomprehensive.In this study,we employed molecular docking and network pharmacology methods to predict the effective compositions,potential target proteins and potential biological pathways.Six compounds were predicted to have potential activity for liver-cancer target proteins.Meanwhile,we analyzed the biological pathways based on compounds-target network,which may be play an important role in liver cancer.This article is presented to explore the active ingredients of P.dindygulensis and provide crucial material for the further research and development of the plant.