Omics in schizophrenia: current progress and future directions of antipsychotic treatments

• 作者: Chen Luan He Lin Huai Cong Huang Hailiang Qin Shengying Sun Yidan Zhou Wei
• 来源期刊: 生物组学研究杂志（英文）
• 关键词: schizophrenia antipsychotics adverse drug reaction drug efficacy omics
• 年，卷（期）: 2019,（4）
• 所属期刊栏目: Review Article
• 页码范围: 145-152
• 页数: 8页
• 语种: 中文
• DOI: 10.1097/JBR.0000000000000049

摘要

Schizophrenia is a life-long, complex mental illness that still lacks satisfactory treatments. In recent years, increasing numbers of candidate biomarkers of schizophrenia occurrences and drug responses to schizophrenia therapies have been successfully identified by many omics studies. This review discusses the latest discoveries regarding effective drug targets and relevant drug classifications in schizophrenia. It also assesses our understanding of biomarkers for drug efficacy and adverse drug reactions in current schizophrenia treatments using omics technologies. Future applications in clinical practice have been proposed based on these new findings, and are now considered highly promising strategies to better treat schizophrenia. Finally, we explore several novel approaches that aim to reveal additional genetic signatures of schizophrenia using multi-omics data, which are hoped to improve the diagnosis and treatment of this illness in the future.