Social Deprivation of Newborn Rats Modifies Exploratory and Defensive Behavior at Mature Age

• 作者: Anna Yu. Shishelova Kirill S. Smirnov Vladimir V. Raevskiy
• 来源期刊: 行为与脑科学期刊(英文)
• 学科: 医学
• 关键词: ONTOGENESIS ABSENCE EPILEPSY BEHAVIOR Wag/Rij Rats
• 年，卷（期）: 2019,（10）
• 页码范围: 375-384
• 页数: 10页
• 分类号: R74

摘要

The effect of complete social deprivation in early postnatal ontogenesis on adult behavior in Wag/Rij rats with a genetic predisposition to the development of absence epilepsy was studied. From the 2nd to the 8th day of life, a 3-hour daily isolation of the pups from the mother and siblings was performed, the control animals were handled. In adulthood, offspring behavior was tested in an elevated plus-maze, an open field, and for an ability to learn the conditioned reflex of active avoidance. In isolated earlier rats, an increase in emotional reactivity, exploratory behavior in a potentially dangerous space, the speed of learning a conditioned reflex with negative painful reinforcement, and a disturbance of the formation of a defensive reaction were revealed. It is assumed that high emotional reactivity creates the prerequisites for the development of absence epilepsy.