Study on the Relationship between Stromal Cell-Derived Factor-1 (SDF-1) and Gastric Cancer

• 作者: Chongshu Wang Shoujiang Wei Xiulian Xu Yurong Song
• 来源期刊: 健康(英文)
• 学科: 医学
• 关键词: SDF-1 CLINICOPATHOLOGICAL Characteristics GASTRIC CANCER HP
• 年，卷（期）: jkyw_2019,（3）
• 页码范围: 332-340
• 页数: 9页
• 分类号: R73

摘要

Whether SDF-1 is related to the occurrence and development of gastric cancer, we collected gastric cancer tissues and corresponding non-cancerous gastric tissues from 52 patients with gastric cancer, and detected the expression of SDF-1 by real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. In both cases SDF-1 gene and protein expression in gastric cancer tissues were significantly higher than in corresponding non-cancerous gastric tissues (both P 0.05, respectively). Also, there were no significant relations hip in gastric cancer tissues of Helicobacter pylori (HP)-positive patients and negative ones (P > 0.05). The result of the study showed that SDF-1 might play a significant role in the process of formation and development of gastric cancer as an oncogene, but could not be used as an index to judge prognosis and predict recurrence.