Fe3O4-based Nanoparticles for pH-responsive Dual-modality Imaging and Photothermal Therapy

• 作者: Jiang Gu Li Fu Qianz Dong
• 来源期刊: 现代肿瘤学研究进展(英文)
• 学科: 化学
• 关键词: Magnetic resonance imaging Diagnostic and therapeutic agents Dual-mode imaging Photothermal therapy
• 年，卷（期）: 2019,（4）
• 页码范围: 14-18
• 页数: 5页
• 分类号: O63

摘要

The study designed a polyacrylic acid(PAA)modified Fe3O4@MnO2 nanoparticles(Fe3O4@MnO2@PAA)for T1/T2 dualmode imaging.In addition,this nano-drug has pH response and anti-tumor photothermal therapy.First,using Fe3O4 as the core can significantly reduce the signal of Fe3O4@MnO2@PAA nanoparticles.MnO2 nanoshells can be decomposed into paramagnetic Mn2+under the acidic environment in the tumor,which enhanced the T1 signal.The pH-responsive T1/T2 dual-mode magnetic resonance imaging(MRI)contrast agent had good sensitivity and specificity,providing more comprehensive and detailed information for tumor diagnosis.In addition,Fe3O4@MnO2@PAA nanoparticles showed excellent absorption capacity in the near-infrared region(NIR),which could be used as a good photothermal conversion material to mediate photothermal treatment of tumors.Therefore,the pHresponsive dual-mode MRI nanoparticle-mediated photothermal therapy showed good application potential in tumor treatment and diagnosis.