The EU-Japan Economic Partnership Agreement coming into force on February 1,2019 has brought into place the largest bilateral free trade framework of the world to date which shall include three tenths of total global economy and four tenths of global trade.The rules system of the agreement shall have profound impact on the running direction of international trade and even that of global politics.At present,contradictions accumulated in the process of globalization tend to intensify,forces of de-globalization and anti-regional integration populism,protectionism and nationalism rise rapidly,and the existing world economic system has encountered serious challenges.The establishment of EU-Japan economic partnership is an important measure taken by the European Union(EU)to respond to the new situation,reflecting the overall consideration of the EU on the layout of its global strategy.