Effect of subconjunctival injection with conbercept as an adjuvant to filtration surgery for open angle glaucoma: a prospective randomized interventional 6-month follow-up study

• 作者: Dong-Lai Chen Jing Zhang Min Ke Ping Wang Qing Wang Tian Zheng Vikash Vikash
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: filtration surgery conbercept 5-FLUOROURACIL open angle GLAUCOMA
• 年，卷（期）: gjykzzywb,（2）
• 页码范围: 235-240
• 页数: 6页
• 分类号: R

摘要

AIM:To compare the safety and efficacy of subconjunctival injection with conbercept and 5-fluorouracil(5-FU) for open angle glaucoma(OAG) patients after filtration surgery. METHODS:As a prospective randomized interventional trial, 36 eyes from 36 patients after OAG surgery were collected and divided randomly into conbercept and 5-FU groups. All patients were subconjunctivally injected with either conbercept(0.2 mL) or 5-FU(0.2 mL) on the 5th day post-operatively. The intraocular pressure(IOP), number of medications used, type of conjunctival bleb, and complications were recorded and analyzed pre-operatively and 1d, 1wk, 1, 3 and 6mo post-injection. RESULTS:There were significant differences in IOP between the conbercept and 5-FU groups 1mo(conbercept group:12.17±1.04 mm Hg;5-FU group:13.50±2.33 mm Hg, t=2.214, P=0.037), 3mo(conbercept group:13.00±1.88 mm Hg;5-FU group:14.50±2.28 mm Hg, t=2.153, P=0.039), and 6mo post-injection(conbercept group:13.28±2.95 mm Hg;5-FU group:15.22±2.49 mm Hg, t=2.140, P=0.040);however, in the number of medications, a prominent difference was not shown between groups on post-injection 6mo(t=1.312, P=0.200). Moreover, there was mild vascularity observed in the conbecept group than the 5-FU group 1d(3a, 3b, 3c:t=8.497, 6.693, 4.515, P=0.000), 1wk(3a, 3b, 3c:t=3.431, 6.408, 3.984, P=0.002, 0.000, 0.000), and 1mo post-injection(3a, 3b, 3c:t=2.466, 2.466, 2.503, P=0.019, 0.019, 0.017). Simultaneously, differences from other indicators between the two groups were not demonstrated. Also, there was a lower probability of corneal epithelial stripping in the conbercept group than the 5-FU group(χ^2=4.500, P=0.034). CONCLUSION:Subconjunctival injection of conbercept has a safe, effective, and tolerable profile for open angle glaucoma patients with distinct conjunctival congestion after filtration surgery.