Intricacies in the cross talk between metabolic enzymes, RNA, and protein translation

• 作者: Miguel A.Esteban Muqddas Tariq Shahzina Kanwal Xiangpeng Guo Yuan Lv
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（10）
• 页码范围: 813-815
• 页数: 3页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz089

摘要

The development of techniques allowing the systematic capture of the RNA-bound proteome has yielded many surprises.Among these, metabolic enzymes have been frequently detected as RNA-binding proteins (RBPs) by different profiling methodologies in various cell types (Hentze et al., 2018).Compared to previous—more simplistic—views, it is now known that cellular metabolism (not only limited to the tricarboxylic acid, TCA, cycle) is compartmentalized.In fact, metabolic enzymes translocate to the nucleus and are enriched at actively transcribed loci, where they sustain epigenetic/epitranscriptomic marks through localized metaboliteproduction (Mews et al., 2017).