The relationship of blood cell-associated inflammatory indices and diabetic retinopathy: a Meta-analysis and systematic review

• 作者: Wen-Fang Zhang Wen-Juan Luo
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: mean PLATELET volume PLATELET distribution width NEUTROPHIL to LYMPHOCYTE RATIO platelet-lymphocyte RATIO diabetic RETINOPATHY
• 年，卷（期）: gjykzzywb,（2）
• 页码范围: 312-323
• 页数: 12页
• 分类号: R

摘要

AIM:To explore the correlation between several blood cell-associated inflammatory indices including mean platelet volume(MPV), platelet distribution width(PDW), neutrophil to lymphocyte ratio(NLR) and platelet-lymphocyte ratio(PLR), and the presence and severity of diabetic retinopathy(DR). METHODS:We searched for eligible studies from PubMed, EMBASE, Web of Science and CNKI up to December 13, 2017. Standardized mean difference(SMD) calculated with confidence interval(CI) of 95% was used to estimate the values of those indices. RESULTS:A total of 31 studies were included in the present Meta-analysis. As compared with type 2 diabetes mellitus(T2 DM) patients without DR, the values of MPV, PDW, NLR, and PLR were higher in patients with DR(SMD=0.67;95%CI:0.36 to 0.98;SMD=0.51;95%CI:0.27 to 0.75;SMD=0.77;95%CI:0.49 to 1.05 and SMD=1.18;95%CI:0.07 to 2.28). Additionally, it was also observed that MPV was closely correlated with the severity of DR. CONCLUSION:MPV, PDW, NLR, and PLR could be recommended as diagnostic biomarkers for DR, and MPV could be applied to assess the severity of DR.