Chromosomal Alterations in Patients with Alzheimer Disease in Manaus,Amazonas,Brazil

• 作者: Cleiton Fantin Denise Corrêa Benzaquem Diana Vieira Brito Ernanda Raquel de Queirós Gon?alves de Sousa e Fernandes Kledson Moraes Nunes Natalia Dayane Moura Carvalho
• 来源期刊: 药剂与药理学:英文版
• 学科: 医学
• 关键词: AD KARYOTYPING numeric CHROMOSOMAL alterations DOUBLE ANEUPLOIDIES multiple ANEUPLOIDIES
• 年，卷（期）: 2019,（8）
• 页码范围: 451-458
• 页数: 8页
• 分类号: R

摘要

Alzheimer disease(AD)is a complex neurodegenerative pathology that is characterized by a cognitive decline.Its causes and mechanisms are still largely unknown.It has been suggested that both genetic and life exposure factors can contribute to AD development.There are also evidences that chromosomal alterations can be related to this disease.So far,there is not a precise diagnosis for AD,which is given only after the exclusion of other dementia by clinical and neurological examination.The possible association of AD with chromosomal alterations and the easy access of classical cytogenetics analysis are important aspects to consider,given the difficulties in diagnosis.Due to the lack of similar studies in Brazil and the increasing number of AD cases in the state of Amazonas,the aim of this study was to investigate the presence of chromosomal alterations in patients diagnosed with AD in Manaus,Amazonas,Brazil.Peripheral blood lymphocytes of twelve patients and twelve healthy individuals with the same age were analyzed using conventional karyotyping.All AD patients presented cells with autosomal aneuploidy,while no chromosomal alterations were found in the age-matched controls.Also,rare events of double and multiple aneuploidies are being reported in association with AD for the first time.Our results corroborate that the increase in the frequencies of aneuploidies is not related to the aging process itself,but it might be associated to the disease development.However,no chromosomes were preferentially affected in all AD patients,and no consistent karyotype pattern for AD lymphocytes was found.Therefore,our results do not support the use of standard cytogenetics as a tool for AD diagnosis.Future studies are necessary to understand better the association between chromosomal alterations and AD.