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摘要:
Background Although recent data in healthy humans suggestthat treatment with intranasal oxytocin(0T)may facilitate extinction recall,to date,little is known about the effects of 0T on memory consolidationprocesses.Aim To examine the effect of intranasal administration of OT compared with placebo on memory consolidation blockade of a de novo fear memory in a classical 2-day fear conditioning procedure.Results There were no significant differences between the 0T and the placebo groups on the first two extinction trials(mean(SD)=0.01(0.39)vs 0.15(0.31),t=-1.092,p=0.28).Similarly,during early extinction,analysis of variance for repeated measures failed to show significant main effects of extinction trials:trials(F(4,112)=1.58,p=0.18),drug(F(1,112)=0.13,p=0.72)or drug x trials interaction(F(4,112)=0.76,p=0.56).Conclusion Our results suggest that 0T administered in a double-blind fashion immediately after fear conditioning does not significantly reduce consolidation of fear learning as measured by a differential skin conductance response tested at the beginning of extinction.
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篇名 Influence of intranasal oxytocin on fear consolidation in healthy humans
来源期刊 综合精神医学(英文) 学科 数学
关键词 EXTINCTION CONSOLIDATION measures
年,卷(期) zhjsyxyw_2019,(6) 所属期刊栏目
研究方向 页码范围 327-334
页数 8页 分类号 O17
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EXTINCTION
CONSOLIDATION
measures
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综合精神医学(英文)
双月刊
2096-5923
31-2152/R
上海市徐汇区宛平南路600号
4-951
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