Opportunities and challenges in the nanoparticles for nucleic acid therapeutics: the first approval of an RNAi nanoparticle for treatment of a rare disease

• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（6）
• 页码范围: 1105-1106
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/nsr/nwz009

摘要

Nanoparticle-based nucleic acid thera-peutics have drawn considerable attention over recent decades.By using terms such as ‘nanoparticle’ and ‘gene delivery’ in a PubMed search,we found that 10 years ago throughout 2008 there were only 725 such papers published;however,in 2017,over 4700 papers were published with the same keywords.The dramatic increase in the number of publications indicates that the field of nanoparticle-based nucleic acid therapeutics,which is a complicated one underpinned by the development of numerous related fields,such as pharmaceutics,material sciences,immunology and cell biology,is thriving.