Synthesis and antibacterial studies of ciprofloxacin-metal complexes

• 作者: Agha Zeeshan Mirza Ahsan Zamir Siddiqi M.Saeed Arayne Najma Sultana
• 来源期刊: 中国药学（英文版）
• 学科: 医学
• 年，卷（期）: 2019,（6）
• 所属期刊栏目: 研究论文
• 页码范围: 422-429
• 页数: 8页
• 分类号: R914
• 语种: 英文

摘要

Metal complexes of ciprofloxacin were synthesized to study the effect of the drug on the metals present in the body or metals co-administered as multivitamin therapy.These complexes were then characterized by IR,UV,1H NMR,CHN and AA analyses.It was found that the metals coordinated through the β-keto carboxylic group,forming four coordinated complexes having square planar geometry.The effect of the antibacterial activity of these complexes with respect to parent drug was also studied against 14 different Gram + ve and Gram-ve organisms by the disk susceptibility technique.Some complexes showed improve activity as compared with the stated drug.