Some Aspects Affecting the Molecular Mechanisms of Eukaryotic Adaptation under Global Warming

• 作者: Igor Yurievich Gorbatenko Lyubov Igorivna Denisyuk Michael Ivanovich Gill Vladimir Pavlovich Novikov
• 来源期刊: 药剂与药理学:英文版
• 学科: 医学
• 关键词: Global WARMING RNA-thermosensors DNA ribonucleic acid (RNA) ENZYMES
• 年，卷（期）: 2019,（11）
• 页码范围: 578-583
• 页数: 6页
• 分类号: R

摘要

Global warming is an irreversible process resulting in the deterioration of living conditions for various organisms, including the most important agricultural species. So-called ζ^32 factor of Escherichia coli is embedded into the RNA-thermosensor in the λ cIII gene and plays an important role in the regulation of bacterial response to hightened temperatures. Expression of heat/cold-shock genes and some virulence genes in response to temperature changes is coordinated by the genome. There are some known RNA-thermosensors with different structures that provide a functional control of the diversity of cellular processes. The most common RNA-thermosensor is the ROSE-element suppressing expression of heat-shock genes. A common feature is functionally important and it is elimination that makes the RNA-thermosensor insensitive to high temperatures. In this paper we describe molecular sequences (RNA-thermosensor) whose chemical compounds influence on the homeostatic temperature regulation, namely, on the corresponding enzymes. Though the data on RNA-thermosensors we obtained for microorganisms it is maybe possible in the long run to change the animal genome at the molecular level by the insertion of these sequences or cultivation of symbiotic microorganisms, which may be used for production of biologically active compounds. In addition, such insertions would probably be able to reduce the negative effect of high environmental temperatures on living organisms.