Background: Today’s lifestyle changes have resulted in changes in the pattern of diseases from infectious diseases to non-communicable diseases. One disease that threatens the community is hypercholesterolemia. Pharmacological therapy was performed often fails due to non-compliance hypercholesterolemia patients. One of the complementary therapies that can be done is by implementing reimprinting. Reimprinting is a development of the SEFT method (Spiritual Emotional Freedom Technique). Reimprinting is the implementation of SEFT therapy independently. Methods: The research design used was quasy experimental with a Randomized Pretest and Posttest Control Group Design. The variables observed in this study were cholesterol levels (total cholesterol, HDL (High Density Lipoprotein), LDL (Low Density Lipoprotein), triglycerides). The group of respondents in this study was divided into 2 groups, namely group 1 (not given an intervention) and group 2 (the group given the reimprinting intervention). To find out the effectiveness of the reimprinting method, a paired-samples t test was used with a significance of 0.05. Result: The results of the study showed that the administration of reimprinting intervention in hypercholesterolemia patients was effective in reducing total cholesterol levels, increasing HDL (High Density Lipoprotein) cholesterol levels and lowering LDL (Low Density Lipoprotein) cholesterol levels. Conclusion: Reimprinting is one type of complementary therapy that can be done as a support for pharmacological therapy given to hypercholesterolemia patients to improve the success of the therapy. To get optimal results, an active role is needed from health personnel to be able to apply reimprinting therapy, obedience of hypercholesterolemia patients to attend each therapy session, active hypercholesterolemia patients should perform therapy independently and obey any advice has been given by health workers to consume drugs routinely and adopt a healthy lifestyle.