Lnc(ing) interferon production and action

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2019,（9）
• 页码范围: 690-691
• 页数: 2页
• 语种: 英文

摘要

Host-virus homeostasis is intricately regulated at multiple steps of both interferon (IFN) induction and IFN action;a recent paper by Zhou et al.has revealed a new feature of this complex regulation.They report the discovery of an IFN-inducible cytoplasmic long non-coding RNA,IncLrrc55-AS,which promotes IRF3 phosphorylation by inactivating the phosphatase PP2A,thus providing a positive feedback loop to IFN induction.