Inhibition Effects of Salvianolic Acid M and Rosmarinic Acid in Salvia deserta Schang on Human Aldose Reductase

• 作者: Jian YANG Jie WU Qian HE Xinling WANG
• 来源期刊: 亚洲农业研究:英文版
• 学科: 医学
• 关键词: SALVIA deserta Schang ALDOSE REDUCTASE Salvianolic ACID M Rosmarinic ACID
• 年，卷（期）: 2019,（8）
• 页码范围: 69-70
• 页数: 2页
• 分类号: R285

摘要

[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.