Restoring Efficacy to Cotrimoxazole, against Resistant <i>Salmonella pullorum, </i>with <i>Medicinal Synthetic Aluminum-Magnesium Silicate <sup>®</sup></i>[MSAMS: Al<sub>4</sub>(SiO<sub>4</sub>)<sub>3</sub>+ 3Mg<sub>2</sub>SiO<sub>4</sub>→ 2Al<sub>2</sub>Mg<sub>3</sub>(SiO<sub>4</sub>)<sub>3</sub>]

• 作者: Aniefiok Emerson Udom Ijeoma Joy Ogbonna Maduike Chiehiura Onwubiko Ezeibe Obiageri Favour Onyeachonam
• 来源期刊: 健康(英文)
• 学科: 医学
• 关键词: Cure for RESISTANT Infections Salmonellosis MSAMS
• 年，卷（期）: 2019,（9）
• 页码范围: 1162-1168
• 页数: 7页
• 分类号: R5

摘要

To restore efficacy (≥95% infection-reduction) to drugs against resistant infections (now, posing a bigger medical challenge, globally, than even HIV/AIDS), Cotrimoxazole was formulated with a synthetic Aluminum-magnesium silicate (Medicinal mineral which molecules are made of Nanoparticles, that is already in use as pharmaceutical-stabilizing agent) and used with antioxidants to treat Cotrimoxazole-resistant Salmonella pulorum infected chicks. Chick-groups A, B and C were fed antioxidants-fortified feed while groups D, E, F, G and H were not. The treatment-groups and their Cotrimoxazole doses/formulations were: A and D (100%/MSAMS-Cotrimoxazole);B and E (75%/MSAMS-Cotrimoxazole);C and F (50%/MSAMS-Cotrimoxazole) and G (100%/Cotrimoxazole). Infection-reductions (96.23% and 94.98%) of the groups of 75%/MSAMS-Cotrimoxazole/antioxidants and 75%/MSAMS-Cotrimoxazole were significantly (P ≤ 0.05) better than 76.99% (100%/Cotrimoxazole);10.04% (50%/MSAMS-Cotrimoxazole/antioxidants);1.60% (50%/MSAMS-Cotrimoxazole);−212.60% (100%/MSAMS-Cotrimoxazole/antioxidants) and −230.96% (100%/MSAMS-Cotrimoxazole).