Forest landscapes are under much pressure globally due to changes in land use and their biodiversity and services are threatened at increasing magnitude especially in the tropics. Biodiversity and ample forest cover still remain in freshwater forest landscapes in the Niger basin of Nigeria, but are declining at astronomical scales across the region. To better understand the changes and modifications going on in the ecosystem at the landscape level, a thirty-year study (1987-2017) was conducted using remotely sensed Landsat imageries. These were processed and used to verify the dynamics in land cover changes and their major drivers. Land use change across the region reduced the forest extent and forest cover (up to 50.2 percent) of the natural ecosystems which served as the habitats for the indigenous species. Sparse vegetation and bare soil/farmlands increased over the study period and were seen as the major indices for modifications and forest loss in the area. Since land use indices such as agricultural activities were seen as one of the major factors of land cover change, sustainable forest use and management practices that accommodate agricultural practices were advocated. While the forest cover and ultimately their biodiversity and conservation prospects reduced following forest loss in the region, efforts should be targeted at conserving the pockets of vegetation seen in the sparsely vegetated zones and also maximize the potentials that the biodiversity in the agro-forested locations offers.