Aberrant alternative splicing in breast cancer

• 作者: Dan Chen Jinyao Zhao Quan Yang Wenjing Zhang Yang Wang
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（10）
• 页码范围: 920-929
• 页数: 10页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz033

摘要

Alternative splicing is critical for human gene expression regulation,which plays a determined role in expanding the diversity of functional proteins.Importantly,alternative splicing is a hallmark of cancer and a potential target for cancer therapeutics.Based on the statistical data,breast cancer is one of the top leading causes of cancer-related deaths in women worldwide.Strikingly,alternative splicing is closely associated with breast cancer development.Here,we seek to provide a general review of the relationship between alternative splicing and breast cancer.We introduce the process of alternative splicing and its regulatory role in cancers.In addition,we highlight the functions of aberrant alternative splicing and mutations of splicing factors in breast cancer progression.Moreover,we discuss the role of alternative splicing in cancer drug resistance and the potential of being targets for cancer therapeutics.