Auto-regulatory feedback by RNA-binding proteins

• 作者: Jan Medenbach Jingyi Hui Michaela Müller-McNicoll Oliver Rossbach
• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（10）
• 页码范围: 930-939
• 页数: 10页
• 语种: 英文
• DOI: 10.1093/jmcb/mjz043

摘要

RNA-binding proteins (RBPs) are key regulators in post-transcriptional control of gene expression.Mutations that alter their activity or abundance have been implicated in numerous diseases such as neurodegenerative disorders and various types of cancer.This highlights the importance of RBP proteostasis and the necessity to tightly control the expression levels and activities of RBPs.In many cases,RBPs engage in an auto-regulatory feedback by directly binding to and influencing the fate oftheir own mRNAs,exerting control over their own expression.For this feedback control,RBPs employ a variety of mechanisms operating at all levels of posttranscriptional regulation of gene expression.Here we review RBP-mediated autogenous feedback regulation that either serves to maintain protein abundance within a physiological range (by negative feedback) or generates binary,genetic on/off switches important for e.g.cell fate decisions (by positive feedback).