Global warming brings a series of problems, including the worsening of drought stress worldwide. This paper aims to find optimal Calcium-using strategies in realistic events of drought stress. Maize seedlings were grown in solutions with differing Ca2+ concentrations, and PEG6000 was used to simulate drought stress. Several physiological indexes were measured to determine the effect of Calcium ions on maize seedlings under drought stress. Results show that a calcium concentration of 10 mM yields best results under both normal and drought conditions, but the lower calcium concentration of 2 mM may be more favorable in short-term drought stress situations.