Nuclear actin switch of the IN080 remodeler

• 来源期刊: 分子细胞生物学报（英文版）
• 年，卷（期）: 2019,（5）
• 页码范围: 343-344
• 页数: 2页
• 语种: 英文
• DOI: 10.1093/jmcb/mjy083

摘要

Eukaryotic DNA is wrapped in nucleosomes,which impede the access of transcription factors and regulatory proteins to template DNA.Chromatin remodelers utilize the energy from ATP hydrolysis to drive histone movement relative to nucleosomal DNA and nucleosome editing.Thus,they play critical roles in transcription,DNA replication,and damage repair,and their dysfunctions are often associated with diseases including cancers (Klages-Mundt et al.,2018).Chromatin remodelers can be generally categorized into INO80,SWI/SNF,CHD,and ISWI subfamilies,which share conserved catalytic ATPase-translocase motors.However,how other auxiliary components of these multi-subunit machinery control their genomic recruitment and actions of DNA translocation remains as a major challenge of the field.