Forkhead domain mutations in FOXA1 drive prostate cancer progression

• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2019,（9）
• 页码范围: 770-772
• 页数: 3页
• 语种: 英文

摘要

Dear Editor, FOXA1 (Forkhead Box Protein A1) is a pioneer transcription factor (TF) that functions to loosen the compact chromatin structure to facilitate binding of other TFs such as estrogen receptor and androgen receptor (AR).1,2 AR is a nuclear receptor functioning as a ligand-dependent TF that plays a pivotal role in driving the initiation of prostate cancer (PCa) and the development of castration-resistant PCa (CRPC).