Dog10K:an international sequencing effort to advance studies of canine domestication, phenotypes and health

• 作者: Brian W. Davis Bridgett M. vonHoldt Christophe Hitte Dog 10K Consortium Elaine A. Ostrander Greger Larson Guo-Dong Wang Robert K. Wayne Vidhya Jagannathan Ya-Ping Zhang
• 来源期刊: 国家科学评论（英文版）
• 年，卷（期）: 2019,（4）
• 页码范围: 810-824
• 页数: 15页
• 语种: 英文
• DOI: 10.1093/nsr/nwz049

摘要

Dogs are the most phenotypically diverse mammalian species, and they possess more known heritable disorders than any other non-human mammal. Efforts to catalog and characterize genetic variation across well-chosen populations of canines are necessary to advance our understanding of their evolutionary history and genetic architecture. To date, no organized effort has been undertaken to sequence the world's canid populations. The Dog10K Consortium (http://www.dog10kgenomes.org) is an international collaboration of researchers from across the globe who will generate 20×whole genomes from 10000 canids in 5 years. This effort will capture the genetic diversity that underlies the phenotypic and geographical variability of modern canids worldwide. Breeds, village dogs, niche populations and extended pedigrees are currently being sequenced, and de novo assemblies of multiple canids are being constructed. This unprecedented dataset will address the genetic underpinnings of domestication, breed formation, aging, behavior and morphological variation. More generally, this effort will advance our understanding of human and canine health.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	Elaine A. Ostrander	中国科学院昆明动物研究所	1	0	0.0	0.0
2	Guo-Dong Wang	中国科学院昆明动物研究所	1	0	0.0	0.0
3	Greger Larson	中国科学院昆明动物研究所	1	0	0.0	0.0
4	Bridgett M. vonHoldt	中国科学院昆明动物研究所	1	0	0.0	0.0
5	Brian W. Davis	中国科学院昆明动物研究所	1	0	0.0	0.0
6	Vidhya Jagannathan	中国科学院昆明动物研究所	1	0	0.0	0.0
7	Christophe Hitte	中国科学院昆明动物研究所	1	0	0.0	0.0
8	Robert K. Wayne	中国科学院昆明动物研究所	1	0	0.0	0.0
9	Ya-Ping Zhang	中国科学院昆明动物研究所	1	0	0.0	0.0
10	Dog 10K Consortium	中国科学院昆明动物研究所	1	0	0.0	0.0