Chorioretinal response to intravitreal aflibercept injection in acute central serous chorioretinopathy

• 作者: Byung Ju Jung Jae Hyung Lee Jin Hyung Park Kook Lee
• 来源期刊: 国际眼科杂志:英文版
• 学科: 医学
• 关键词: AFLIBERCEPT ACUTE central SEROUS CHORIORETINOPATHY anti-vascular ENDOTHELIAL growth factor choroidal hyperpermeability choroidal thickness
• 年，卷（期）: 2019,（12）
• 页码范围: 1865-1871
• 页数: 7页
• 分类号: R58

摘要

AIM: To evaluate chorioretinal responses to intravitreal aflibercept injection(IAI) in patients with acute central serous chorioretinopathy(CSC). METHODS: Seventy-one eyes from 71 patients with symptomatic CSC for less than six months were included. Thirty-five eyes received a single IAI and 36 eyes were observed without treatment. Best-corrected visual acuity(BCVA), central subfield foveal thickness(CSFT), and subfoveal choroidal thickness(SFCT) were assessed at baseline and at 1, 2, and 3 mo. RESULTS: The mean SFCT in the IAI group decreased at 1 mo, rebounded at 2 mo and remained stable at 3 mo compared to the baseline, while significant change was not noted in the observation group. The mean CSFT decreased significantly during the 3-month study period in both groups, and was significantly lower in the IAI group at 1 mo(P<0.001). A rebound of CSFT between 1 and 2 mo was noted in 14 eyes(40.0%) in the IAI group and in 1 eye(2.8%) in the observation group(P<0.001). The significant visual improvement was achieved from 1 mo in the IAI group, and from 2 mo in the observation group. The rate of complete absorption of subretinal fluid at 3 mo did not differ between the two groups.(45.7% vs 41.7%, P=0.813). CONCLUSION: A single IAI for acute CSC induce a transient decrease in SFCT and CSFT, which implies that IAI may have a pharmacological effect on the underlying hyperpermeable choroid in acute CSC.